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Serum Levels of M2BPGi as Short-Term Predictors of Hepatocellular Carcinoma in Untreated Chronic Hepatitis B Patients.
- Source :
-
Scientific reports [Sci Rep] 2017 Oct 30; Vol. 7 (1), pp. 14352. Date of Electronic Publication: 2017 Oct 30. - Publication Year :
- 2017
-
Abstract
- This study examines the role of M2BPGi, a novel seromarker for chronic hepatitis, in predicting hepatocellular carcinoma (HCC) among untreated chronic hepatitis B (CHB) patients. In this nested case-control study, 1070 samples were assayed for M2BPGi, including 357 samples from HCC cases, and 713 samples from non-HCC controls, collected at various times throughout follow-up. HCC case samples were stratified according to years prior to diagnosis. Associations between M2BPGi and HCC were examined with multivariate logistic regression. M2BPGi, α-fetoprotein (AFP), and hepatitis B surface antigen (HBsAg) levels were significant independent short-term predictors of HCC, while M2BPGi was insignificant in long-term analyses. Compared to M2BPGi levels <1.0 cut-off index (COI), those with levels ≥2.0 COI had multivariate odds ratios (95% CI) for HCC of 7.40 (2.40-22.78), 6.46 (2.58-16.18), and 2.24 (0.97-5.15), respectively, for prediction of HCC within 1-2, 2-5, and ≥5 years. Higher proportions of individuals had M2BPGi levels ≥2.0 COI in samples closer to HCC diagnosis. Areas under receiver operating characteristic curves for models with M2BPGi, AFP, and HBsAg levels predicting HCC within 1-2, 2-5, and >5 years were 0.84, 0.81, and 0.75. M2BPGi is a strong and independent short-term predictor of HCC in CHB patients.
- Subjects :
- Adult
Aged
Antigens, Neoplasm blood
Antiviral Agents therapeutic use
Area Under Curve
Biomarkers, Tumor blood
Carcinoma, Hepatocellular blood
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular metabolism
Carrier Proteins blood
Case-Control Studies
Female
Glycoproteins blood
Hepatitis B Surface Antigens analysis
Hepatitis B Surface Antigens blood
Hepatitis B, Chronic complications
Hepatitis B, Chronic drug therapy
Humans
Liver Cirrhosis complications
Liver Neoplasms blood supply
Liver Neoplasms drug therapy
Liver Neoplasms metabolism
Male
Middle Aged
Prognosis
ROC Curve
alpha-Fetoproteins analysis
Antigens, Neoplasm analysis
Biomarkers, Tumor analysis
Carrier Proteins analysis
Glycoproteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29085039
- Full Text :
- https://doi.org/10.1038/s41598-017-14747-5