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Lung-Infiltrating Foxp3 + Regulatory T Cells Are Quantitatively and Qualitatively Different during Eosinophilic and Neutrophilic Allergic Airway Inflammation but Essential To Control the Inflammation.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Dec 15; Vol. 199 (12), pp. 3943-3951. Date of Electronic Publication: 2017 Nov 01. - Publication Year :
- 2017
-
Abstract
- Understanding functions of Foxp3 <superscript>+</superscript> regulatory T cells (Tregs) during allergic airway inflammation remains incomplete. In this study, we report that, during cockroach Ag-induced allergic airway inflammation, Foxp3 <superscript>+</superscript> Tregs are rapidly mobilized into the inflamed lung tissues. However, the level of Treg accumulation in the lung was different depending on the type of inflammation. During eosinophilic airway inflammation, ∼30% of lung-infiltrating CD4 T cells express Foxp3, indicative of Tregs. On the contrary, only ∼10% of infiltrating CD4 T cells express Foxp3 during neutrophilic airway inflammation. Despite the different accumulation, the lung inflammation and inflammatory T cell responses were aggravated following Treg depletion, regardless of the type of inflammation, suggesting regulatory roles for Tregs. Interestingly, however, the extent to which inflammatory responses are aggravated by Treg depletion was significantly greater during eosinophilic airway inflammation. Indeed, lung-infiltrating Tregs exhibit phenotypic and functional features associated with potent suppression. Our results demonstrate that Tregs are essential regulators of inflammation, regardless of the type of inflammation, although the mechanisms used by Tregs to control inflammation may be shaped by environmental cues available to them.<br /> (Copyright © 2017 by The American Association of Immunologists, Inc.)
- Subjects :
- Adjuvants, Immunologic administration & dosage
Adjuvants, Immunologic toxicity
Allergens administration & dosage
Allergens immunology
Alum Compounds administration & dosage
Alum Compounds toxicity
Alveolitis, Extrinsic Allergic etiology
Alveolitis, Extrinsic Allergic pathology
Animals
Cockroaches immunology
Disease Models, Animal
Forkhead Transcription Factors analysis
Freund's Adjuvant administration & dosage
Freund's Adjuvant toxicity
Gene Expression Profiling
Genes, Reporter
Immunophenotyping
Inflammation
Insect Proteins administration & dosage
Insect Proteins immunology
Lung pathology
Mice, Inbred C57BL
Pulmonary Eosinophilia etiology
Pulmonary Eosinophilia pathology
Specific Pathogen-Free Organisms
Alveolitis, Extrinsic Allergic immunology
Lung immunology
Neutrophil Infiltration immunology
Pulmonary Eosinophilia immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 199
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 29093062
- Full Text :
- https://doi.org/10.4049/jimmunol.1700211