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Anti-obesity Effect of Halophyte Crop, Limonium tetragonum in High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes.
Anti-obesity Effect of Halophyte Crop, Limonium tetragonum in High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2017; Vol. 40 (11), pp. 1856-1865. - Publication Year :
- 2017
-
Abstract
- Halophyte Limonium tetragonum has recently been of interest in Korea for its nutritional value and salty taste which made it an ideal vegetable. In this study, the potential of L. tetragonum preventing excess weight gain, obesity and the related health problem has been evaluated in vitro and in vivo. The treatment with 100 mg/kg of L. tetragonum EtOAc soluble fraction (EALT) apparently prevented the body weight gain, adipose tissue weight gain, and the increase of triglyceride and total cholesterol level in mice fed a high-fat diet for 8 weeks. In addition, both glucose tolerance and insulin resistance in dietary obese mice were improved by EALT administration. A marked decrease in adipocyte differentiation was observed in the EALT (50 µg/mL)-treated 3T3-L1 cells, which was mediated by the suppression of adipogenesis-related transcription factors including peroxisome proliferator-activated receptor (PPAR) γ, CCAAT/enhancer binding protein (C/EBP)α, and Sterol regulatory element binding protein-1 (SREBP-1) and adipocyte-specific proteins such as fatty acid synthase (FAS), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein (aP2). The major components contained in EALT were identified as (-)-epigallocatechin-3-(3″-O-methyl) gallate, (-)-epigallocatechin-3-gallate, and myricetin-3-O-β-D-galactopyranoside based on its phytochemical analysis. Results suggested that EALT might be available as functional crop and bioactive diet supplement for the prevention and/or treatment of obesity.
- Subjects :
- 3T3-L1 Cells
Adipocytes drug effects
Adipocytes metabolism
Animals
Anti-Obesity Agents pharmacology
Blood Glucose
Diet, High-Fat adverse effects
Dietary Supplements
Disease Models, Animal
Glucose Tolerance Test
Humans
Insulin Resistance
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity blood
Obesity etiology
Phytochemicals pharmacology
Phytochemicals therapeutic use
Plant Extracts pharmacology
Republic of Korea
Triglycerides blood
Weight Gain drug effects
Adipogenesis drug effects
Anti-Obesity Agents therapeutic use
Obesity prevention & control
Plant Extracts therapeutic use
Plumbaginaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5215
- Volume :
- 40
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 29093332
- Full Text :
- https://doi.org/10.1248/bpb.b17-00296