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Factors associated with prolonged time to treatment failure with fulvestrant 500 mg in patients with post-menopausal estrogen receptor-positive advanced breast cancer: a sub-group analysis of the JBCRG-C06 Safari study.
- Source :
-
Current medical research and opinion [Curr Med Res Opin] 2018 Jan; Vol. 34 (1), pp. 49-54. Date of Electronic Publication: 2017 Nov 21. - Publication Year :
- 2018
-
Abstract
- Objective: The JBCRG-C06 Safari study showed that earlier fulvestrant 500 mg (F500) use, a longer time from diagnosis to F500 use, and no prior palliative chemotherapy were associated with significantly longer time to treatment failure (TTF) among Japanese patients with estrogen receptor-positive (ER+) advanced breast cancer (ABC). The objective of this sub-group analysis was to further examine data from the Safari study, focusing on ER + and human epidermal growth factor receptor-negative (HER2-) cases.<br />Methods: The Safari study (UMIN000015168) was a retrospective, multi-center cohort study, conducted in 1,072 patients in Japan taking F500 for ER + ABC. The sub-analysis included only patients administered F500 as second-line or later therapy (n = 960). Of these, 828 patients were HER2-. Results Multivariate analysis showed that advanced age (≥65 years; p = .035), longer time (≥3 years) from ABC diagnosis to F500 use (p < .001), no prior chemotherapy (p < .001), and F500 treatment line (p < .001) were correlated with prolonged TTF (median = 5.39 months).<br />Conclusions: In ER+/HER2- patients receiving F500 as a second-line or later therapy, treatment line, advanced age, no prior palliative chemotherapy use, and a longer period from ABC diagnosis to F500 use were associated with longer TTF.
- Subjects :
- Adult
Aged
Aged, 80 and over
Breast Neoplasms chemistry
Estradiol therapeutic use
Female
Fulvestrant
Humans
Middle Aged
Postmenopause
Retrospective Studies
Time-to-Treatment
Treatment Failure
Antineoplastic Agents, Hormonal therapeutic use
Breast Neoplasms drug therapy
Estradiol analogs & derivatives
Receptors, Estrogen analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1473-4877
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current medical research and opinion
- Publication Type :
- Academic Journal
- Accession number :
- 29095648
- Full Text :
- https://doi.org/10.1080/03007995.2017.1400426