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Simultaneous monitoring of electroencephalographic characteristics in animals subjected to behavioral tests: a preclinical investigation.
- Source :
-
Behavioural pharmacology [Behav Pharmacol] 2017 Dec; Vol. 28 (8), pp. 661-669. - Publication Year :
- 2017
-
Abstract
- Drug-induced changes in electroencephalographic (EEG) characteristics in animals may be used to predict central activity of drugs in humans. Previous studies have established that drugs affect EEG characteristics in humans and rodents in a similar manner. However, there has been little work to establish correlations between drug effects on behavioral and EEG characteristics in rats. In the current study, we have simultaneously monitored EEG characteristics during a novel object recognition task (NORT) or open field (OF) test in rats. EEG was monitored using telemetric device from epidural and hippocampal regions during the choice trial in the NORT after treatment with scopolamine (0.1 mg/kg, intraperitoneal) alone or in combination with donepezil (0.3 mg/kg, subcutaneous). Power changes across spectral frequency bands during exploration of novel and familiar object were assessed separately. Amphetamine (2 mg/kg, intraperitoneal) was used to monitor effects on locomotor activity and EEG changes in the OF test. In the NORT, scopolamine impaired object recognition, but no differences were observed in the power densities across spectral bands during exploration of novel and familiar objects. Treatment with donepezil reversed scopolamine-induced cognitive impairment, and the power density in the theta frequency band was increased during exploration of the novel object. In OF, amphetamine increased locomotion and produced an overall decrease in the power densities of all frequency bands. Overall, the results indicate that EEG characteristics are closely related to behavioral changes in the NORT and OF in rodents.
- Subjects :
- Amphetamine pharmacology
Animals
Brain drug effects
Donepezil
Electrodes, Implanted
Exploratory Behavior drug effects
Indans pharmacology
Male
Motor Activity drug effects
Neuropsychological Tests
Piperidines pharmacology
Rats, Wistar
Recognition, Psychology drug effects
Scopolamine pharmacology
Telemetry
Brain physiology
Central Nervous System Agents pharmacology
Electrocorticography
Exploratory Behavior physiology
Motor Activity physiology
Recognition, Psychology physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5849
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Behavioural pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 29099402
- Full Text :
- https://doi.org/10.1097/FBP.0000000000000364