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Vitamin D (25-OHD) deficiency may increase the prevalence of medication-related osteonecrosis of the jaw.
- Source :
-
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery [J Craniomaxillofac Surg] 2017 Dec; Vol. 45 (12), pp. 2068-2074. Date of Electronic Publication: 2017 Sep 23. - Publication Year :
- 2017
-
Abstract
- Introduction: Osteonecrosis of the jaw (ONJ) is a severe complication of antiresorptive medication (AM) in the treatment of bone-affecting cancer-related conditions and osteoporosis. Aim of this study was to reveal whether patients treated with AM and show Medication Related OsteoNecrosis of the Jaw (MRONJ) are vitamin D deficient or not.<br />Materials and Methods: A 2 year retrospective study evaluated hospital records of 63 patients who received AM. Patients were divided into two groups. One group (n = 45) consisted of patients who presented a stage 2 ONJ (eb+ = exposed bone). Second group patients (n = 18) (eb- = no exposed bone) presented for extraction of teeth. Serum levels of vitamin D (25-OHD) were analysed. P values ≤ 0.05 in t-test were regarded as statistically significant.<br />Results: Serum levels of 25-OHD were significantly higher in the eb(-) group (29.5 ng/ml), than in the eb(+) group (20.49 ng/ml). Blood levels of calcium were also significantly higher in eb(-) group (2.25 mmol/L; 0.11 SD) than in eb(+) group (2.175 mmol/L; 0.16 SD).<br />Conclusion: Prevalence of MRONJ in AM treated patients seems to be increased by low serum 25-OHD. A measurable tendency in the role of 25-OHD for the development of MRONJ was recorded and leads to the recommendation for a sufficient vitamin D substitution in patients treated with AM.<br /> (Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Jaw Diseases etiology
Male
Middle Aged
Osteonecrosis etiology
Prevalence
Retrospective Studies
Bone Density Conservation Agents adverse effects
Jaw Diseases chemically induced
Jaw Diseases epidemiology
Osteonecrosis chemically induced
Osteonecrosis epidemiology
Vitamin D analogs & derivatives
Vitamin D Deficiency complications
Subjects
Details
- Language :
- English
- ISSN :
- 1878-4119
- Volume :
- 45
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 29102331
- Full Text :
- https://doi.org/10.1016/j.jcms.2017.09.015