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Design of injectable agar-based composite hydrogel for multi-mode tumor therapy.

Authors :
Wu C
Zhao J
Hu F
Zheng Y
Yang H
Pan S
Shi S
Chen X
Wang S
Source :
Carbohydrate polymers [Carbohydr Polym] 2018 Jan 15; Vol. 180, pp. 112-121. Date of Electronic Publication: 2017 Oct 06.
Publication Year :
2018

Abstract

We designed an injectable hydrogel by dissolving MoS <subscript>2</subscript> /Bi <subscript>2</subscript> S <subscript>3</subscript> -PEG (MBP), doxorubicin (DOX) and agar into water for the concurrent tumor photothermal and chemotherapy. The formed solution was able to be intra-tumorally (I.T.) administered into tumor at a relatively high temperature and automatically formed a hydrogel after cooling to body temperature. The resultant Agar/MBP/DOX (AMD) hydrogel can act as a macro-vessel to retain the MBP nanosheet and DOX and restrict their access to body fluid circulation. Moreover, AMD hydrogel did not compromise the photoacoustic and computed tomography imaging capacity, as well as the photothermal and chemotherapy efficiency of MBP nanosheets and DOX. The heat from the photothermal transformation of MBP nanosheet can promote the drug-release from the hydrogel and thus enable an on-demand drug release. Furthermore, antibiotics were also able to be encapsulated in the hydrogel to avoid the potential wound infection during tumor surgery.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-1344
Volume :
180
Database :
MEDLINE
Journal :
Carbohydrate polymers
Publication Type :
Academic Journal
Accession number :
29103486
Full Text :
https://doi.org/10.1016/j.carbpol.2017.10.024