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Can molecular profiling enhance radiotherapy? Impact of personalized targeted gold nanoparticles on radiosensitivity and imaging of adenoid cystic carcinoma.
- Source :
-
Theranostics [Theranostics] 2017 Sep 14; Vol. 7 (16), pp. 3962-3971. Date of Electronic Publication: 2017 Sep 14 (Print Publication: 2017). - Publication Year :
- 2017
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Abstract
- Personalized molecular profiling has an established role in selection of treatment for metastatic disease; however, its role in improving radiosensitivity and functional imaging has not been evaluated. In the current study, we examined molecular profiling as a tool for designing personalized targeted gold nanoparticles (GNP) to serve as dual-modal tumor radiosensitizers and functional imaging enhancers. To this end, molecular profiling of a patient's salivary gland adenoid cystic carcinoma (ACC) was performed, and anaplastic lymphoma kinase (ALK) mutation was detected. The extracted tumor was subcutaneously injected into mice, which were then treated either with radiation, the specific ALK inhibitor crizotinib, or a combination of therapies. One of these combinations, namely, ALK-targeted GNP (via crizotinib coating), was found to enhance radiation treatment, as demonstrated by a significant decrease in tumor volume over 24 days. In parallel, ALK-targeted GNP substantially augmented tumor visualization via computed tomography. The mechanism of radiosensitivity enhancement was mostly related to a diminished cell repair mechanism in tumors, as demonstrated by proliferating cell nuclear antigen staining. These findings indicate that personalized molecular profiling is an effective technique for enhancing cancer theranostics.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.
- Subjects :
- Anaplastic Lymphoma Kinase
Carcinoma, Adenoid Cystic drug therapy
Carcinoma, Adenoid Cystic metabolism
Crizotinib
Humans
Mutation genetics
Pyrazoles therapeutic use
Pyridines therapeutic use
Receptor Protein-Tyrosine Kinases metabolism
Carcinoma, Adenoid Cystic diagnostic imaging
Gold chemistry
Metal Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1838-7640
- Volume :
- 7
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Theranostics
- Publication Type :
- Academic Journal
- Accession number :
- 29109791
- Full Text :
- https://doi.org/10.7150/thno.19615