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Effect of Red Light-Emitting Diodes Irradiation on Hemoglobin for Potential Hypertension Treatment Based on Confocal Micro-Raman Spectroscopy.
- Source :
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Scanning [Scanning] 2017 Jan 12; Vol. 2017, pp. 5067867. Date of Electronic Publication: 2017 Jan 12 (Print Publication: 2017). - Publication Year :
- 2017
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Abstract
- Red light-emitting diodes (LED) were used to irradiate the isolated hypertension hemoglobin (Hb) and Raman spectra difference was recorded using confocal micro-Raman spectroscopy. Differences were observed between the controlled and irradiated Hb by comparing the spectra records. The Raman spectrum at the 1399 cm <superscript>-1</superscript> band decreased following prolonged LED irradiation. The intensity of the 1639 cm <superscript>-1</superscript> band decreased dramatically in the first five minutes and then gradually increased in a time-dependent manner. This observation indicated that LED irradiation increased the ability of oxygen binding in Hb. The appearance of the heme aggregation band at 1399 cm <superscript>-1</superscript> , in addition to the oxygen marker band at 1639 cm <superscript>-1</superscript> , indicated that, in our study, 30 min of irradiation with 15.0 mW was suitable for inhibiting heme aggregation and enhancing the oxygen-carrying capacity of Hb. Principal component analysis showed a one-to-one relationship between irradiated Hb at different time points and the corresponding Raman spectra. Our approach could be used to analyze the hemoglobin from patients with confocal micro-Raman spectroscopy and is helpful for developing new nondrug hypertension therapy.<br />Competing Interests: The authors declare that they have no competing interests.
Details
- Language :
- English
- ISSN :
- 1932-8745
- Volume :
- 2017
- Database :
- MEDLINE
- Journal :
- Scanning
- Publication Type :
- Academic Journal
- Accession number :
- 29109818
- Full Text :
- https://doi.org/10.1155/2017/5067867