Back to Search
Start Over
Multiple sclerosis and HLA genotypes: A possible influence on brain atrophy.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2019 Jan; Vol. 25 (1), pp. 23-30. Date of Electronic Publication: 2017 Nov 07. - Publication Year :
- 2019
-
Abstract
- Background: The strongest genetic determinant for multiple sclerosis (MS) is located at the human leukocyte antigen (HLA) class II DRB1 and DQB1 loci.<br />Objectives: To investigate the possible role of predisposing HLA genotypes in determining brain atrophy.<br />Methods: HLA genotypes were categorized as high risk (two predisposing haplotypes) or medium/low risk (one or no predisposing haplotypes). Patients underwent a brain magnetic resonance imaging (MRI) study and volumes of white matter (WM), gray matter (GM), and whole brain (WB) were estimated with SIENAX. Longitudinal atrophy was also assessed with SIENA.<br />Results: The study included 240 MS patients. In 51/240 (21%) subjects, a high-risk HLA genotype was observed, while medium- and low-risk HLA genotypes were 109/240 (45%) and 80/240 (34%), respectively. Multiple regression analysis found that the high-risk HLA genotype was associated with significant reduction in WB ( pā=ā0.02) and GM ( pā=ā0.03) volumes compared with the medium-/low-risk HLA genotypes, independently from MS clinical features. The longitudinal study included 60 patients and showed a brain volume loss of -0.79% in high-risk HLA genotype group versus -0.56% in low-risk HLA genotype.<br />Conclusion: Our results suggest an influence of HLA genotype on WB and GM atrophy. Further investigations are necessary to confirm these findings.
- Subjects :
- Adult
Atrophy
Brain
Female
Gray Matter diagnostic imaging
HLA-DQ beta-Chains genetics
HLA-DRB1 Chains genetics
Humans
Italy
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis diagnostic imaging
White Matter diagnostic imaging
Gray Matter pathology
HLA-D Antigens genetics
Multiple Sclerosis genetics
Multiple Sclerosis pathology
White Matter pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 29111883
- Full Text :
- https://doi.org/10.1177/1352458517739989