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Potassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2α ablation.
- Source :
-
Neuroreport [Neuroreport] 2018 Jan 03; Vol. 29 (1), pp. 59-64. - Publication Year :
- 2018
-
Abstract
- Cytosolic phospholipase A2α (cPLA2α) is implicated in the progression of excitotoxic neuronal injury and cerebral ischemia. Previous work suggests that cPLA2α increases aberrant electrophysiologic events through attenuating K channel functions. Nevertheless, which K channels are affected by cPLA2α needs to be determined. Here we examined K channels-mediated electrophysiologic responses in hippocampal CA1 pyramidal neurons from wild-type and cPLA2α mice using simultaneous patch-clamp recording and confocal Ca imaging. After the exposure to the blockers of Ca-sensitive and A-type K channels, all CA1 neurons developed spike broadening and increased dendritic Ca transients. These effects were occluded in CA1 neurons from cPLA2α mice. Therefore, cPLA2α modulates the functions of Ca-sensitive and A-type K channels in neurotoxicity.
- Subjects :
- 2S Albumins, Plant genetics
4-Aminopyridine pharmacology
Action Potentials drug effects
Action Potentials genetics
Animals
Apamin pharmacology
Calcium metabolism
Electric Stimulation
Electrophysiological Phenomena
In Vitro Techniques
Mice
Mice, Transgenic
Patch-Clamp Techniques
Paxillin pharmacology
Potassium Channel Blockers pharmacology
Pyramidal Cells drug effects
2S Albumins, Plant metabolism
Hippocampus cytology
Potassium Channels metabolism
Pyramidal Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1473-558X
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 29112675
- Full Text :
- https://doi.org/10.1097/WNR.0000000000000933