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MicroRNA-375 as a potential serum biomarker for the diagnosis, prognosis, and chemosensitivity prediction of osteosarcoma.
- Source :
-
The Journal of international medical research [J Int Med Res] 2018 Mar; Vol. 46 (3), pp. 975-983. Date of Electronic Publication: 2017 Nov 08. - Publication Year :
- 2018
-
Abstract
- Objective This study was performed to examine serum microRNA-375 (miR-375) expression in patients with osteosarcoma and determine its diagnostic and prognostic value. Methods Serum samples were obtained from 95 patients with osteosarcoma and 95 healthy individuals. miR-375 expression was detected by real-time polymerase chain reaction. The associations of serum miR-375 expression with the patients' clinicopathological characteristics and prognosis were then evaluated. Receiver operating characteristic curve analysis was performed to obtain the potential value of serum miR-375 as a biomarker for osteosarcoma diagnosis and chemosensitivity prediction. Results Serum miR-375 expression was significantly lower in patients with osteosarcoma than in healthy individuals. Low serum miR-375 levels were associated with advanced clinical stages, large tumor size, positive distant metastasis, and poor tumor response to preoperative chemotherapy. Receiver operating characteristic curve analysis illustrated that serum miR-375 could distinguish patients with osteosarcoma from healthy individuals and distinguish patients with a good pathologic response from those with a poor response. Multivariate analysis confirmed low serum miR-375 expression as a statistically significant independent unfavorable prognostic factor. Conclusions Serum miR-375 expression was downregulated in patients with osteosarcoma and might serve as a biomarker for its diagnosis, prognosis, and chemosensitivity prediction.
- Subjects :
- Adolescent
Adult
Biomarkers, Tumor blood
Bone Neoplasms drug therapy
Bone Neoplasms genetics
Bone Neoplasms mortality
Case-Control Studies
Child
Doxorubicin therapeutic use
Female
Humans
Male
Methotrexate therapeutic use
MicroRNAs blood
Neoadjuvant Therapy methods
Neoplasm Staging
Osteosarcoma drug therapy
Osteosarcoma genetics
Osteosarcoma mortality
Prognosis
ROC Curve
Survival Analysis
Treatment Outcome
Tumor Burden drug effects
Biomarkers, Tumor genetics
Bone Neoplasms diagnosis
MicroRNAs genetics
Osteosarcoma diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1473-2300
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 29115164
- Full Text :
- https://doi.org/10.1177/0300060517734114