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The mutational landscape of small lymphocytic lymphoma compared to non-early stage chronic lymphocytic leukemia.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2018 Oct; Vol. 59 (10), pp. 2318-2326. Date of Electronic Publication: 2017 Nov 08. - Publication Year :
- 2018
-
Abstract
- Small lymphocytic lymphoma (SLL) is considered as the non-leukemic form of presentation of chronic lymphocytic leukemia (CLL). We have compared the features, genomic alterations, and outcome of 890 patients with CLL and SLL. One hundred and thirteen patients presented as SLL and more frequently had unmutated-IGHV, CD38 <superscript>high</superscript> , ZAP-70 <superscript>high</superscript> , CD49d <superscript>high</superscript> , +12, alterations in genes of NOTCH1, cell cycle, RNA metabolism, and NFkB pathways than CLL. During the follow-up, 46% of SLL patients developed CLL. Time to first treatment (TTFT) was shorter in SLL (10-year: 75% vs 62%; p = .006). Binet stage, SLL, and IGHV were independent predictive factors for TTFT. Transformation to diffuse large B-cell lymphoma was higher (10-year: 12% vs 6%; p = .003), and overall survival was shorter in SLL (10-year: 55% vs 66%; p = .004). When A0 CLL patients were excluded, only CD38 and CD49d expression, +12, and 10-year TTFT remained different between the SLL and CLL patients. In summary, SLL showed only minor clinicobiological differences when compared with CLL in similar clinical stages.
- Subjects :
- Adult
Aged
Aged, 80 and over
DNA Mutational Analysis
Female
Follow-Up Studies
Humans
Leukemia, Lymphocytic, Chronic, B-Cell drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell mortality
Leukemia, Lymphocytic, Chronic, B-Cell pathology
Male
Middle Aged
Neoplasm Staging
Survival Analysis
Time-to-Treatment statistics & numerical data
Young Adult
Genome, Human genetics
Leukemia, Lymphocytic, Chronic, B-Cell genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 59
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 29115891
- Full Text :
- https://doi.org/10.1080/10428194.2017.1397660