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Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement.
- Source :
-
Nutrients [Nutrients] 2017 Nov 11; Vol. 9 (11). Date of Electronic Publication: 2017 Nov 11. - Publication Year :
- 2017
-
Abstract
- Background: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL.<br />Methods: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients. Patients with deficiency were evaluated again after one year vitamin supplementation.<br />Results: 25-OHD was low in 111 patients and was negatively related to exacerbations ( p < 0.001), inhaled CS dose ( p = 0.008) and asthma severity ( p = 0.001). Deficiency was found in 90 patients, 55 of whom took the supplement regularly for one year, while 24 discontinued the study and 11 were not adherent. Patients with vitamin D deficiency after 12 months supplementation showed significant decrease of exacerbations (from 2.6 ± 1.2 to 1.6 ± 1.1, p < 0.001), circulating eosinophils (from 395 ± 330 to 272 ± 212 10⁶/L, p < 0.001), and need of oral CS courses (from 35 to 20, p = 0.007) and improvement of airway obstruction.<br />Conclusions: Asthma exacerbations are favored by vitamin D deficiency and decrease after long-term vitamin D replacement. Patients who are vitamin D deficient benefit from vitamin D supplementation.<br />Competing Interests: The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
- Subjects :
- Administration, Inhalation
Adolescent
Adult
Aged
Aged, 80 and over
Asthma complications
Asthma diagnosis
Asthma physiopathology
Biomarkers blood
Cross-Sectional Studies
Disease Progression
Female
Humans
Longitudinal Studies
Lung physiopathology
Male
Middle Aged
Retrospective Studies
Time Factors
Treatment Outcome
Vitamin D blood
Vitamin D Deficiency blood
Vitamin D Deficiency complications
Vitamin D Deficiency diagnosis
Young Adult
Adrenal Cortex Hormones administration & dosage
Asthma drug therapy
Cholecalciferol administration & dosage
Dietary Supplements
Lung drug effects
Vitamin D analogs & derivatives
Vitamin D Deficiency drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 9
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 29137124
- Full Text :
- https://doi.org/10.3390/nu9111234