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Associations between Th17-related inflammatory cytokines and asthma in adults: A Case-Control Study.
- Source :
-
Scientific reports [Sci Rep] 2017 Nov 14; Vol. 7 (1), pp. 15502. Date of Electronic Publication: 2017 Nov 14. - Publication Year :
- 2017
-
Abstract
- Chronic airway inflammation is recognized as an essential process in the pathogenesis of asthma. Cytokine profiles derived from immune and inflammation cells such as T-helper (Th) cells, eosinophilia and neutrophilia are not limited to the Th2 type in asthma. However, little is understood about associations between Th2-low inflammatory cytokine profiles and risk of asthma in adults. A case-control study of 910 adult asthma and 881 healthy controls was conducted. Inflammatory cytokines screening was undertaken by high-throughput protein microarray technology, and Th17-related inflammatory cytokines (IL17A, IL-9, adipsin and CCL11) were finally selected. Associations between these four cytokines and adult asthma risk were analyzed by multivariate logistic regression models. We observed that plasma IL-17A and IL-9 levels were significantly increased in asthmatics when compared with controls. However, the plasma expressions of adipsin and CCL11 in asthmatics were significantly lower than that in health controls. The adjusted ORs (95%CI) of association between IL-17A, IL-9, adipsin and CCL11 expressions and adult asthma were 3.08 (1.91, 4.97), 1.93 (1.41, 2.64), 10.02 (6.99, 14.37) and 3.29 (2.36, 4.59), respectively (all P <subscript>trend</subscript> < 0.0001). Our results suggested that elevated IL-17A and IL-9 expressions and decreased levels of adipsin and CCL11 were positively associated with adult asthma.
- Subjects :
- Adult
Asthma immunology
Asthma pathology
Biomarkers metabolism
Case-Control Studies
Chemokine CCL11 immunology
Complement Factor D genetics
Complement Factor D immunology
Female
Gene Expression
Gene Expression Profiling
Humans
Interleukin-17 immunology
Interleukin-9 immunology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Oligonucleotide Array Sequence Analysis
Risk Factors
Th17 Cells pathology
Th2 Cells immunology
Th2 Cells pathology
Asthma genetics
Chemokine CCL11 genetics
Interleukin-17 genetics
Interleukin-9 genetics
Th17 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29138487
- Full Text :
- https://doi.org/10.1038/s41598-017-15570-8