Back to Search
Start Over
MAGE-A4 and MAGE-A1 Immunohistochemical Expression in High-grade Endometrial Cancer.
- Source :
-
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists [Int J Gynecol Pathol] 2019 Jan; Vol. 38 (1), pp. 59-65. - Publication Year :
- 2019
-
Abstract
- The aim was to investigate MAGE-A4 and MAGE-A1 protein expression in high-grade endometrial cancer and determine its correlation with histologic subtype, FIGO stage, presence of vascular invasion, disease free, and overall survival. Immunohistochemical staining was performed by using 77B (MAGE-A1) and 57B (MAGE-A4) monoclonal antibodies on paraffin-embedded sections from high-grade endometrial cancers diagnosed in University Hospital Split between 1998 and 2011 (n=77). Median follow-up time for survivors was 48 mo. MAGE-A4 was found to be expressed in 33% of endometrioid type endometrial cancers grade 3 and in 27% of serous and clear cell carcinomas. MAGE-A1 was found to be expressed in 93% endometrioid endometrial cancer grade 3 and 86% of serous and clear cell carcinomas. Univariate analysis showed that positive immunohistochemical staining for MAGE-A4 was associated with decreased disease free and overall survival in patients with high-grade endometrial cancer. Multivariate analysis showed an association between MAGE-A4 overexpression and decreased disease free but not overall survival in high-grade endometrial cancer. No correlation was found between MAGE-A1 immunohistochemical expression and patient survival. There was no significant correlation between MAGE-A4 and MAGE-A1 expression and histologic subtype, FIGO stage, lymph node metastasis, muscular infiltration, and lymphovascular invasion. MAGE-A4 immunohistochemical expression is associated with decreased disease free and overall survival in patients with high-grade endometrial cancer. Our findings suggest that MAGE-A1 may be expressed in the epithelial cells of the normal endometrium. MAGE-A1 is highly expressed in high-grade endometrial cancer, with no impact on survival.
- Subjects :
- Adenocarcinoma, Clear Cell metabolism
Adenocarcinoma, Clear Cell mortality
Antibodies, Monoclonal
Carcinoma, Endometrioid metabolism
Carcinoma, Endometrioid mortality
Endometrial Neoplasms metabolism
Endometrial Neoplasms mortality
Endometrium pathology
Female
Humans
Immunohistochemistry
Lymphatic Metastasis
Neoplasm Grading
Retrospective Studies
Survival Analysis
Adenocarcinoma, Clear Cell pathology
Antigens, Neoplasm metabolism
Carcinoma, Endometrioid pathology
Endometrial Neoplasms pathology
Neoplasm Proteins metabolism
Peptide Fragments metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7151
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
- Publication Type :
- Academic Journal
- Accession number :
- 29140883
- Full Text :
- https://doi.org/10.1097/PGP.0000000000000470