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Ecotropic Viral Integration Site 5 (EVI5) variants are associated with multiple sclerosis in Iranian population.
- Source :
-
Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2017 Nov; Vol. 18, pp. 15-19. Date of Electronic Publication: 2017 Sep 14. - Publication Year :
- 2017
-
Abstract
- Background: Multiple sclerosis (MS) is a multifactorial disorder with immunological basis. Numerous genetic and environmental factors contribute in its pathogenesis. Several genetic loci have been shown to be associated with MS risk. Among genes whose participation in MS has been evaluated is Ecotropic Viral Integration Site 5 (EVI5). EVI5 is a common site of retroviral integration with a possible role in T-cell lymphomagenesis.<br />Methods: In the current study, we aimed to confirm association of the single nucleotide polymorphisms (SNPs) within EVI5 gene with MS in 410 relapsing-remitting MS patients and 410 controls from Iranian population. The rs6680578, rs10537781 and rs11810217 genotypes were defined by amplification-refractory mutation system (ARMS)-PCR method.<br />Results: The allele and genotype frequencies of rs6680578 and rs11810217 were not significantly different between cases and controls. However, in the rs10735781 the GG genotype was significantly associated with MS risk in recessive (P = 0.03, OR (95%CI) = 1.84 (1.05-3.19)) and co-dominant models (P = 0.02, OR 95%CI) = 1.90 (1.08-3.35)). In addition, T G T haplotype (rs6680578, rs10735781 and rs11810217 respectively) was associated with MS risk while T C C, A G T and A C T had a protective effect against MS.<br />Conclusion: The results of the current study provide further evidences for participation of EVI5 in MS pathogenesis.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Cell Cycle Proteins
Female
GTPase-Activating Proteins
Gene Frequency
Genetic Association Studies
Humans
Iran
Linkage Disequilibrium
Male
Middle Aged
Models, Genetic
Virus Integration genetics
Young Adult
Genetic Predisposition to Disease
Multiple Sclerosis, Relapsing-Remitting genetics
Nuclear Proteins genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 2211-0356
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis and related disorders
- Publication Type :
- Academic Journal
- Accession number :
- 29141798
- Full Text :
- https://doi.org/10.1016/j.msard.2017.09.011