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Biogenic selenium and its hepatoprotective activity.
- Source :
-
Scientific reports [Sci Rep] 2017 Nov 15; Vol. 7 (1), pp. 15627. Date of Electronic Publication: 2017 Nov 15. - Publication Year :
- 2017
-
Abstract
- Elemental selenium nanoparticles (SeNPs) have multiple biological activities. In this study, we investigated the protective effects of biogenic SeNPs (BioSeNPs) on CCl <subscript>4</subscript> -induced liver damage in mice. The results showed that: (i) when compared to sodium selenite (SS), BioSeNPs has a similar tissue distribution after intragastrical administration to mice; (ii) BioSeNPs and SS showed comparable efficacy in increasing the activities of glutathione peroxidase and thioredoxin reductase in liver cell lines, mice blood and liver; (iii) pretreatment with BioSeNPs inhibiting the elevation of activities of various enzymes significantly which included aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase and liver lipid peroxide (p < 0.05 or p < 0.01) in CCl <subscript>4</subscript> -treated mice; (iv) activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) were significantly increased (p < 0.05 or p < 0.01) after a pretreatment with BioSeNPs in CCl <subscript>4</subscript> -treated mice; (v) histopathological damages in the liver from CCl <subscript>4</subscript> -treated mice were ameliorated by a pretreatment with BioSeNPs. In conclusion, these results have shown that BioSeNPs is able to protect the liver from CCl <subscript>4</subscript> -induced hepatic damage via increasing the antioxidant capacity and inhibiting oxidative damage. BioSeNPs may have the potential to be used as a trace element food supplement inducing antioxidant bioactivities.
- Subjects :
- Animals
Antioxidants administration & dosage
Carbon Tetrachloride toxicity
Carbon Tetrachloride Poisoning metabolism
Carbon Tetrachloride Poisoning pathology
Cell Line
Chemical and Drug Induced Liver Injury metabolism
Chemical and Drug Induced Liver Injury pathology
Glutathione Peroxidase genetics
Humans
Metal Nanoparticles chemistry
Mice
Selenium metabolism
Sodium Selenite administration & dosage
Thioredoxin-Disulfide Reductase genetics
Carbon Tetrachloride Poisoning drug therapy
Chemical and Drug Induced Liver Injury drug therapy
Metal Nanoparticles administration & dosage
Selenium administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29142221
- Full Text :
- https://doi.org/10.1038/s41598-017-13636-1