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Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population.

Authors :
Li X
Wang R
Liu Y
Liu Y
Zheng H
Feng Y
Zhao N
Geng H
Zhang W
Wen A
Source :
BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2017 Nov 16; Vol. 18 (1), pp. 73. Date of Electronic Publication: 2017 Nov 16.
Publication Year :
2017

Abstract

Background: Metolazone is a diuretic, saluretic and antihypertensive chemical compound from the quinazoline category that possesses medicinal features similar to those of other thiazide diuretic drugs. However, the pharmacokinetics of metolazone in the Chinese population has rarely been studied. This study aimed to examine the pharmacokinetic characteristics, safety characteristic, and tolerability of metolazone in healthy Chinese subjects after single and multiple doses taken orally as well as the effects that food and gender have on oral metolazone pharmacokinetic parameters.<br />Methods: An open-label, randomized, and single- and multiple-dosing investigation was performed in healthy Chinese subjects. The investigation included 3 study groups: the 0.5 mg, 1 mg and 2 mg dose groups were the single-dose study groups in the first stage. Eligible volunteers were randomly and orally administered a single 0.5 mg, 1 mg, or 2 mg metolazone tablet. The 0.5 mg dose group was also part of the multiple-dose study group, and the 1 mg dose group was the food-effect study group in the second stage. Human plasma samples were gathered pre-dosing and up to 48 h after dosing. The human plasma sample concentration of metolazone was quantified using a validated liquid chromatography tandem mass spectrometry method. Pharmacokinetic data were calculated by a noncompartmental analysis method using WinNonlin version 6.4. Tolerability was evaluated based on adverse events, medical examination, 12-lead ECG, and other clinical laboratory exams.<br />Results: Thirty eligible subjects (15 men and 15 women) were registered in our investigation and completed all of the study stages. The AUC and C <subscript>max</subscript> showed dose proportionality after a single dose based on the linear-regression analysis. A comparison of the pharmacokinetic data revealed that the differences between the male and female groups were not statistically significant. The t <subscript>max</subscript> of metolazone was increased by approximately 100% in the fed condition. Metolazone was well tolerated at the tested dose, and no adverse effects were observed.<br />Conclusions: Single dosing with 0.5 mg, 1 mg, or 2 mg metolazone yielded linear plasma pharmacokinetic properties in healthy Chinese subjects. Multiple oral doses of metolazone did not display significantly different distributions or elimination characteristics from those observed for a single dose. Gender factors did not appear to influence the pharmacokinetic parameter variation of metolazone. The t <subscript>max</subscript> of metolazone increased in the fed condition. Metolazone was well tolerated at the tested dose in this study.<br />Trial Registration: This investigation is retrospectively registered at chictr.org.cn (ChiCTR-IIR-17012929, October 09 2017).

Details

Language :
English
ISSN :
2050-6511
Volume :
18
Issue :
1
Database :
MEDLINE
Journal :
BMC pharmacology & toxicology
Publication Type :
Academic Journal
Accession number :
29145890
Full Text :
https://doi.org/10.1186/s40360-017-0178-x