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Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts.
- Source :
-
Chemical research in toxicology [Chem Res Toxicol] 2017 Dec 18; Vol. 30 (12), pp. 2097-2099. Date of Electronic Publication: 2017 Nov 22. - Publication Year :
- 2017
-
Abstract
- The risk of developing hypersensitivity to alternative antibiotics is a concern for penicillin hypersensitive patients and healthcare providers. Herein we use piperacillin hypersensitivity as a model to explore the reactivity of drug-specific IgG against alternative β-lactam protein adducts. Mass spectrometry was used to show the drugs (amoxicillin, flucloxacillin, benzyl penicillin, aztreonam, and piperacillin) bind to similar lysine residues on the protein carrier bovine serum albumin. However, the hapten-specific IgG antibodies found in piperacillin hypersensitive patient plasma did not bind to other β-lactam protein conjugates. These data outline the fine specificity of piperacillin-specific IgG antibodies that circulate in patients with hypersensitivity.
Details
- Language :
- English
- ISSN :
- 1520-5010
- Volume :
- 30
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Chemical research in toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 29148816
- Full Text :
- https://doi.org/10.1021/acs.chemrestox.7b00291