Rapid and simplified synthesis of [ 18 F]Fluoromisonidazole and its use in PET imaging in an experimental model of subarachnoid hemorrhage.

Authors :: Fernandez-Maza L
Egea-Guerrero JJ
Balcerzyk M
Civantos-Jubera G
Gordillo-Escobar E
Vilches-Arenas A
Fernandez-Gomez I
Parrado-Gallego A
Murillo-Cabezas F
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2018 Feb; Vol. 132, pp. 79-84. Date of Electronic Publication: 2017 Oct 03.
Publication Year :: 2018
Abstract: Cerebral damage secondary to the vasospasm due to subarachnoid hemorrhage (SAH) is an important cause of morbid-mortality. We propose the use of the PET tracer [ <superscript>18</superscript> F]Fluoromisonidazole to visualize the hypoxia due to the vasospasm. On the other hand [ <superscript>18</superscript> F]Fluoromisonidazole synthesis process was optimized, avoiding HPLC purification using SPE cartridges instead, and reducing some synthesis steps. [ <superscript>18</superscript> F]Fluoromisonidazole in vitro stability was tested for ten hours, and in vivo PET/CT images showed higher cerebral uptake in hemorrhagic animals than in control rats.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Chromatography, High Pressure Liquid
Disease Models, Animal
Humans
Male
Misonidazole chemical synthesis
Misonidazole chemistry
Misonidazole pharmacokinetics
Rats, Wistar
Solid Phase Extraction
Fluorine Radioisotopes chemistry
Misonidazole analogs & derivatives
Positron Emission Tomography Computed Tomography
Subarachnoid Hemorrhage diagnostic imaging

Language :: English
ISSN :: 1872-9800
Volume :: 132
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 29172058
Full Text :: https://doi.org/10.1016/j.apradiso.2017.09.035

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