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An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease.
- Source :
-
Antiviral research [Antiviral Res] 2018 Jan; Vol. 149, pp. 143-149. Date of Electronic Publication: 2017 Nov 22. - Publication Year :
- 2018
-
Abstract
- A common childhood affliction of viral origin in young children and immunocompromised adults, the Hand, Foot and Mouth Disease (HFMD) has become a significant public health concern in the Asia-Pacific Region. Characterized by the appearance of vesiculopapular rashes on the hands, feet and mouth, the disease is generally mild and self-limiting. In a minority of cases, patients can develop neurological complications that could result in permanent morbidity or even fatality. In the absence of a specific antiviral for treatment, medical care is limited to supportive and symptomatic relief, presenting a need for more research into an effective antiviral to be used in the management of the disease. In this study, we evaluated the efficacy of chloroquine, a FDA-approved lysosomotropic agent, against several serotypes of HFMD-associated enteroviruses, including EV-A71, in reducing infectious virus production. We have also evaluated chloroquine in a murine model of EV-A71 infection to ascertain its antiviral efficacy in vivo. The results suggest that chloroquine could be a broad-acting antiviral effective against HFMD-associated enteroviruses.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antiviral Agents therapeutic use
Chloroquine therapeutic use
Disease Models, Animal
Enterovirus A, Human classification
Hand, Foot and Mouth Disease drug therapy
Hand, Foot and Mouth Disease mortality
Humans
Kaplan-Meier Estimate
Mice
Serogroup
Treatment Outcome
Viral Load
Antiviral Agents pharmacology
Chloroquine pharmacology
Enterovirus A, Human drug effects
Hand, Foot and Mouth Disease virology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9096
- Volume :
- 149
- Database :
- MEDLINE
- Journal :
- Antiviral research
- Publication Type :
- Academic Journal
- Accession number :
- 29175128
- Full Text :
- https://doi.org/10.1016/j.antiviral.2017.11.017