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Complex signal-based optical coherence tomography angiography enables in vivo visualization of choriocapillaris in human choroid.

Authors :
Chu Z
Chen CL
Zhang Q
Pepple K
Durbin M
Gregori G
Wang RK
Source :
Journal of biomedical optics [J Biomed Opt] 2017 Nov; Vol. 22 (12), pp. 1-10.
Publication Year :
2017

Abstract

The choriocapillaris (CC) plays an essential role in maintaining the normal functions of the human eye. There is increasing interest in the community to develop an imaging technique for visualizing the CC, yet this remains underexplored due to technical limitations. We propose an approach for the visualization of the CC in humans via a complex signal-based optical microangiography (OMAG) algorithm, based on commercially available spectral domain optical coherence tomography (SD-OCT). We show that the complex signal-based OMAG was superior to both the phase and amplitude signal-based approaches in detailing the vascular lobules previously seen with histological analysis. With this improved ability to visualize the lobular vascular networks, it is possible to identify the feeding arterioles and draining venules around the lobules, which is important in understanding the role of the CC in the pathogenesis of ocular diseases. With built-in FastTrac™ and montage scanning capabilities, we also demonstrate wide-field SD-OCT angiograms of the CC with a field of view at 9×11  mm2.<br /> ((2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).)

Details

Language :
English
ISSN :
1560-2281
Volume :
22
Issue :
12
Database :
MEDLINE
Journal :
Journal of biomedical optics
Publication Type :
Academic Journal
Accession number :
29178697
Full Text :
https://doi.org/10.1117/1.JBO.22.12.121705