Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects.

Authors :: Giacalone G
Zanoletti M
Contini D
Re R
Spinelli L
Roveri L
Torricelli A
Source :: Biomedical optics express [Biomed Opt Express] 2017 Oct 12; Vol. 8 (11), pp. 4987-5000. Date of Electronic Publication: 2017 Oct 12 (Print Publication: 2017).
Publication Year :: 2017
Abstract: The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far. Besides, reference intervals of cerebral optical properties, of absolute concentrations of deoxygenated-hemoglobin (HbR), oxygenated-hemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO <subscript>2</subscript> ) and their variability have not been reported. We have addressed these issues on a sample of 88 adult healthy subjects. TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for semi-infinite homogenous media. Reproducibility, performed on 3 measurements at 5 minutes intervals, ranges from 1.8 to 6.9% for each of the hemoglobin species. The mean ± SD global values of HbR, HbO, HbT, StO <subscript>2</subscript> are respectively 24 ± 7 μM, 33.3 ± 9.5 μM, 57.4 ± 15.8 μM, 58 ± 4.2%. StO <subscript>2</subscript> displays the narrowest range of variability across brain regions.

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