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Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats.
- Source :
-
Animal science journal = Nihon chikusan Gakkaiho [Anim Sci J] 2018 Mar; Vol. 89 (3), pp. 513-526. Date of Electronic Publication: 2017 Dec 07. - Publication Year :
- 2018
-
Abstract
- To expand our understanding of the roles of thyroid hormones on female reproduction, we induced hypo- and hyper-T rat models to investigate the roles of thyroid hormones on estrous cyclicity, as well as the antioxidative status in the ovaries of rats. In the current study, our data show that hypothyroidism (hypo-T) and hyperthyroidism (hyper-T) led to significantly reduced body weights and ovarain weights and delayed vaginal opening day. For hyper-T, thyroxine (T4), tri-iodothyronine (T3), progesterone (P4) and follicle-stimulating hormone (FSH) were significantly increased, while estradiol (E2) and luteinizing hormone (LH) were significantly decreased. For hypo-T rats, serum levels of total T4 and T3, E2, P4, FSH and LH were significantly increased, while concentrations of E2 and LH were significantly decreased. For ovary morphology, the numbers of secondary and antral follicles were significantly decreased with more atretic antral follicles and less corpora lutea in both hyper- and hypo-T groups. Both hyper-T and hypo-T treatment significantly decreased the expressions of thyroid hormone receptor α1 in the ovary. Hypo-T significantly reduced nitric oxide (NO), total NO synthase (tNOS), inducible NOS and constitutive NOS activities, but hyper-T increased them. For antioxidative parameters, hypo-T and hyper-T treatment significantly increased malondialdehyde (MDA) contents. The activities of both glutathione peroxidase (GSH-Px) and catalase (CAT) significantly decreased in the hypo-T group but increased in the hyper-T group. Total superoxide dismutase (T-SOD) activity was significantly increased in the hyper-T group. In summary, thyroid hormones alter estrous cyclicity and antioxidative status in the ovary of the rat may act through the NOS signaling pathway.<br /> (© 2017 Japanese Society of Animal Science.)
- Subjects :
- Animals
Body Weight
Catalase metabolism
Estradiol metabolism
Female
Follicle Stimulating Hormone metabolism
Glutathione Peroxidase metabolism
Hyperthyroidism metabolism
Hypothyroidism metabolism
Luteinizing Hormone metabolism
Malondialdehyde metabolism
Nitric Oxide metabolism
Nitric Oxide Synthase metabolism
Organ Size
Ovary anatomy & histology
Ovary pathology
Rats, Sprague-Dawley
Superoxide Dismutase metabolism
Thyroid Hormone Receptors alpha metabolism
Antioxidants metabolism
Estrous Cycle
Ovary metabolism
Ovary physiology
Thyroid Hormones physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1740-0929
- Volume :
- 89
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Animal science journal = Nihon chikusan Gakkaiho
- Publication Type :
- Academic Journal
- Accession number :
- 29214681
- Full Text :
- https://doi.org/10.1111/asj.12950