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Spontaneous intracerebral hemorrhage as presentation of atypical central neurocytoma: the role of angiogenesis through the characterization of tumor endothelial cells.

Authors :
Marfia G
Pirola E
Navone SE
Beretta M
Guarnaccia L
Trombetta E
Franzini A
Rampini P
Campanella R
Source :
Histology and histopathology [Histol Histopathol] 2018 Jul; Vol. 33 (7), pp. 665-672. Date of Electronic Publication: 2017 Dec 07.
Publication Year :
2018

Abstract

A 36-year-old white man presented with sudden-onset headache and rapid deterioration of consciousness. Computer tomography revealed a right capsular intra-parenchimal hemorrhage with an intraventricular component; therefore, emergency surgery was performed. Once the hematoma was evacuated, the cause of the hemorrhage was identified as a tumor mass and it was resected. Histopathological and immunohistochemical examinations of the surgical specimen disclosed a diagnosis of atypical central neurocytoma. By using a protocol recently set up in our laboratory, we succeeded in isolating and propagating, for the first time, human endothelial cells from central neurocytoma (CN-ECs). Different analyses revealed that isolated CN-ECs consist of a pure endothelial cell population, with the expression of endothelial markers (CD31, CD309/VEGFR2, CD105, eNOS) and with angiogenic properties, such as the uptake of LDL. Moreover, CN-ECs spontaneously organize in a vascular-like structure. The goal of this case report is to stress the need for further studies focused on understanding the causes of the onset of an intra-parenchimal hemorrhage in the presence of an atypical central neurocytoma in order to tailor treatments to each single patient and achieve the best clinical outcome.

Details

Language :
English
ISSN :
1699-5848
Volume :
33
Issue :
7
Database :
MEDLINE
Journal :
Histology and histopathology
Publication Type :
Academic Journal
Accession number :
29215136
Full Text :
https://doi.org/10.14670/HH-11-953