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High treatment persistence rate and significant endoscopic healing among real-life patients treated with vedolizumab - a Finnish Nationwide Inflammatory Bowel Disease Cohort Study (FINVEDO) .
- Source :
-
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2018 Feb; Vol. 53 (2), pp. 158-167. Date of Electronic Publication: 2017 Dec 19. - Publication Year :
- 2018
-
Abstract
- Objectives: The efficacy and tolerability of vedolizumab in the treatment of inflammatory bowel diseases (IBD) has been demonstrated in an extensive GEMINI clinical trial programme. Clinical trials represent highly selected patient populations and, therefore, it is important to demonstrate effectiveness in real-life clinical practice. We set out to assess real-world treatment outcomes of vedolizumab in a nationwide cohort of treatment refractory Finnish Crohn's disease (CD) and ulcerative colitis (UC) patients.<br />Methods: This was a nationwide, retrospective, non-interventional, multi-centre chart review study. All adult patients from 27 Finnish gastroenterology centers with a diagnosis of UC or CD who had at least one vedolizumab infusion since the availability of the product in Finland, were included in the study. Data were collected retrospectively from medical charts at baseline, week 14, and month 6. The primary outcome measure was treatment persistence 24 weeks post-vedolizumab initiation.<br />Results: A total of 247 patients were included (108 CD, 139 UC). A total of 75.0% (n = 81) of all CD patients and 66.2% (n = 92) of all UC patients, were persistent on vedolizumab therapy for 6 months post treatment initiation. At month 6, 41.8% (28/67) of the treatment persistent CD patients and 73.3% (63/86) of the treatment persistent UC patients achieved clinical remission. Significant improvement in endoscopic scores were observed among treatment persistent patients (CD, n = 17, ΔSES-CD=-5.5, p = .008; UC, n = 26, ΔMayo endoscopic score =-0.5, p = .003) at month 6.<br />Conclusions: Vedolizumab provides an effective and well-tolerated treatment option in real-world clinical practice even among treatment refractory IBD patients.
- Subjects :
- Adult
Antibodies, Monoclonal, Humanized adverse effects
Biological Therapy
Endoscopy
Female
Finland
Gastrointestinal Agents adverse effects
Humans
Male
Middle Aged
Remission Induction
Retrospective Studies
Severity of Illness Index
Wound Healing drug effects
Young Adult
Antibodies, Monoclonal, Humanized therapeutic use
Colitis, Ulcerative drug therapy
Crohn Disease drug therapy
Gastrointestinal Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1502-7708
- Volume :
- 53
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 29258369
- Full Text :
- https://doi.org/10.1080/00365521.2017.1416160