Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia.

Authors :: Cáceres DH
Zuluaga A
Tabares ÁM
Chiller T
González Á
Gómez BL
Source :: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2017 Dec 21; Vol. 59, pp. e76. Date of Electronic Publication: 2017 Dec 21.
Publication Year :: 2017
Abstract: A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

Subjects :: Colombia
Cryptococcosis blood
Cryptococcosis cerebrospinal fluid
Humans
Point-of-Care Testing
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Antigens, Fungal blood
Antigens, Fungal cerebrospinal fluid
Chromatography, Affinity methods
Cryptococcosis diagnosis
Cryptococcus immunology

Full Text Access

Tools