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Utilization of Proteins and Peptides to Create Organic-Hydroxyapatite Hybrids.
- Source :
-
Protein and peptide letters [Protein Pept Lett] 2018; Vol. 25 (1), pp. 25-33. - Publication Year :
- 2018
-
Abstract
- Background: Various types of proteins play important roles in the biomineralization of hydroxyapatite (HAp, Ca10(PO4)6(OH)2). The resulting organic-HAp nanohybrids have highlyorganized hierarchical structures that show unique morphological, structural, and mechanical properties. By mimicking the biomineralization process, organic-HAp hybrid materials have been created by utilizing proteins and peptides.<br />Objectives: In this review, firstly the roles of proteins in HAp mineralization in vivo are briefly explained. Recent progresses in the creation of organic-HAp hybrids through the utilization of proteins and peptides are then described.<br />Results: Roles of collagen and amelogenin on the formation of bones and teeth were explained. Then, recent advances, including those by the authors, in the creation of organic-HAp hybrids through the utilization of these proteins, their derivatives, and synthetic peptides, including engineering- isolated ones, were reviewed.<br />Conclusion: Organic-HAp hybrid materials have been intensively created by utilizing proteins and peptides. Among them, engineering-isolated or rationally designed peptides and their derivatives represent future promising building components for organic-HAp hybrids with precise hierarchical structures. Not only the excellent functions of the resultant hybrids materials, but also the creation of materials by biomimetic synthetic processes at a low cost and environmental burden are important for sustainable industrial development.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Details
- Language :
- English
- ISSN :
- 1875-5305
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Protein and peptide letters
- Publication Type :
- Academic Journal
- Accession number :
- 29268681
- Full Text :
- https://doi.org/10.2174/0929866525666171221115033