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The anti-caries effects of dental adhesive resin influenced by the position of functional groups in quaternary ammonium monomers.
- Source :
-
Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2018 Mar; Vol. 34 (3), pp. 400-411. Date of Electronic Publication: 2017 Dec 18. - Publication Year :
- 2018
-
Abstract
- Objectives: A new quaternary ammonium monomer (QAM), triethylaminododecyl acrylate (TEADDA) was synthesized, in which the position of the functional groups was different from that of dimethylaminododecyl methacrylate (DMADDM). The objectives were to: (1) investigate the effect of the changed position of the functional groups on the mechanical properties, anti-biofilm activity and biocompatibility of adhesive resin, and (2) study the anti-bacterial mechanism of QAM to improve the performance of the adhesive system modified by QAM.<br />Methods: TEADDA and DMADDM were added into adhesives. Microtensile bond strength and surface charge density were measured. Multi-species biofilms were incubated on specimens for 16h, 48h and 72h and analyzed via MTT assay, lactic acid measurement and confocal laser scanning microscopy. The ratio of different species of bacteria was measured by real-time polymerase chain reaction. Cytotoxicity and biocompatibility were analyzed by eluents cytotoxicity test and histological images of H&E staining via an animal study in rats.<br />Results: The mass fraction of TEDDA allowed to be added into adhesive was higher than that of DMADDM. However, even 10% TEADDA did not yield a strong anti-biofilm effect on biofilm growth, lactic acid production and bacteria compositions. TEADDA added into adhesives showed better mechanical properties but weaker anti-bacterial effect. There was no significant difference on cytotoxicity and biocompatibility between DMADDM and TEADDA.<br />Significance: The study could be helpful for the investigation of the anti-caries mechanism of QAMs, the design of new QAMs and the improvement of the anti-caries activity of the modified dental materials.<br /> (Copyright © 2017 The Academy of Dental Materials. All rights reserved.)
- Subjects :
- Animals
Biomechanical Phenomena
Lactic Acid analysis
Materials Testing
Microscopy, Confocal
Rats
Real-Time Polymerase Chain Reaction
Tensile Strength
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Biocompatible Materials chemical synthesis
Biocompatible Materials pharmacology
Biofilms drug effects
Dental Caries prevention & control
Dental Cements chemical synthesis
Dental Cements pharmacology
Quaternary Ammonium Compounds chemical synthesis
Quaternary Ammonium Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0097
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Dental materials : official publication of the Academy of Dental Materials
- Publication Type :
- Academic Journal
- Accession number :
- 29269159
- Full Text :
- https://doi.org/10.1016/j.dental.2017.11.021