SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA.

Authors :: Jia Y
Li Z
Cai W
Xiao D
Han S
Han F
Bai X
Wang K
Liu Y
Li X
Guan H
Hu D
Source :: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2018 Mar; Vol. 1864 (3), pp. 784-792. Date of Electronic Publication: 2017 Dec 19.
Publication Year :: 2018
Abstract: Molecular mechanisms for macrophage immune responses modulated by SIRT1 during sepsis remain unclear. Here, we show that SIRT1 expression is down-regulated in macrophages from mouse sepsis model or LPS stimulation. SIRT1 expression in macrophages correlates with low levels of a long noncoding RNA (lncRNA)-NONMMUT003701 [named as lncRNA-CCL2]. SIRT1 inhibits lncRNA-CCL2 expression via sustaining a repressive chromatin state in the lncRNA-CCL2 locus. The inflammation cytokines expression is downregulated by knockdown of lncRNA-CCL2. Such inhibition can be reversed partly by decreased SIRT1 activity. Thus, this work uncovers previously unidentified mechanisms in which SIRT1 associates with lncRNA and lncRNA regulates macrophage inflammatory response.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

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