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Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2018 Feb 15; Vol. 182, pp. 180-187. Date of Electronic Publication: 2017 Nov 07. - Publication Year :
- 2018
-
Abstract
- In this paper, novel cationic chitosan derivative possessing 1,2,3-triazolium and pyridinium groups was synthesized conveniently via cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) and methylation. FTIR, <superscript>1</superscript> H NMR, and elemental analysis examined the structural characteristics of the synthesized derivatives. The antifungal efficiencies of chitosan derivatives against three plant-threatening fungi were assayed by hypha measurement in vitro. The determination showed that chitosan derivative bearing 1,2,3-triazolium and pyridinium displayed tremendously enhanced antifungal activity as compared with chitosan and chitosan derivative bearing 1,2,3-triazole and pyridine. Notably, the inhibitory indices of it against Colletotrichum lagenarium attained 98% above at 1.0mg/mL. The results showed that N-methylation of 1,2,3-triazole and pyridine could effectively enhance antifungal activity of the synthesized chitosan derivatives. Besides, the prepared chitosan derivatives showed non-toxic effect on cucumber seedlings. This synthetic strategy might provide an effective way and notion to prepare novel cationic chitosan antifungal biomaterials.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antifungal Agents chemical synthesis
Antifungal Agents chemistry
Cations chemical synthesis
Cations chemistry
Cations pharmacology
Chitosan chemical synthesis
Chitosan chemistry
Dose-Response Relationship, Drug
Microbial Sensitivity Tests
Molecular Structure
Pyridinium Compounds chemistry
Structure-Activity Relationship
Triazoles chemistry
Antifungal Agents pharmacology
Chitosan pharmacology
Fusarium drug effects
Pyridinium Compounds pharmacology
Triazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 182
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 29279113
- Full Text :
- https://doi.org/10.1016/j.carbpol.2017.11.023