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The Banff Working Group Classification of Definitive Polyomavirus Nephropathy: Morphologic Definitions and Clinical Correlations.
- Source :
-
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2018 Feb; Vol. 29 (2), pp. 680-693. Date of Electronic Publication: 2017 Dec 26. - Publication Year :
- 2018
-
Abstract
- Polyomavirus nephropathy (PVN) is a common viral infection of renal allografts, with biopsy-proven incidence of approximately 5%. A generally accepted morphologic classification of definitive PVN that groups histologic changes, reflects clinical presentation, and facilitates comparative outcome analyses is lacking. Here, we report a morphologic classification scheme for definitive PVN from the Banff Working Group on Polyomavirus Nephropathy, comprising nine transplant centers in the United States and Europe. This study represents the largest systematic analysis of definitive PVN undertaken thus far. In a retrospective fashion, clinical data were collected from 192 patients and correlated with morphologic findings from index biopsies at the time of initial PVN diagnosis. Histologic features were centrally scored according to Banff guidelines, including additional semiquantitative histologic assessment of intrarenal polyomavirus replication/load levels. In-depth statistical analyses, including mixed effects repeated measures models and logistic regression, revealed two independent histologic variables to be most significantly associated with clinical presentation: intrarenal polyomavirus load levels and Banff interstitial fibrosis ci scores. These two statistically determined histologic variables formed the basis for the definition of three PVN classes that correlated strongest with three clinical parameters: presentation at time of index biopsy, serum creatinine levels/renal function over 24 months of follow-up, and graft failure. The PVN classes 1-3 as described here can easily be recognized in routine renal biopsy specimens. We recommend using this morphologic PVN classification scheme for diagnostic communication, especially at the time of index diagnosis, and in scientific studies to improve comparative data analysis.<br /> (Copyright © 2018 by the American Society of Nephrology.)
- Subjects :
- Adult
Biopsy
Creatinine blood
Female
Fibrosis
Glomerular Filtration Rate
Humans
Kidney Diseases physiopathology
Kidney Diseases virology
Kidney Transplantation adverse effects
Male
Middle Aged
Prognosis
Retrospective Studies
Viral Load
Virus Replication
Kidney pathology
Kidney Diseases classification
Kidney Diseases pathology
Polyomavirus physiology
Polyomavirus Infections complications
Tumor Virus Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 1533-3450
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Publication Type :
- Academic Journal
- Accession number :
- 29279304
- Full Text :
- https://doi.org/10.1681/ASN.2017050477