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Familial pneumothorax: towards precision medicine.
- Source :
-
Thorax [Thorax] 2018 Mar; Vol. 73 (3), pp. 270-276. Date of Electronic Publication: 2017 Dec 28. - Publication Year :
- 2018
-
Abstract
- One in 10 patients suffering from primary spontaneous pneumothoraces has a family history of the disorder. Such familial pneumothoraces can occur in isolation, but can also be the presentation of serious genetic disorders with life-threatening vascular or cancerous complications. As the pneumothorax frequently precedes the more dangerous complications by many years, it provides an opportunity to intervene in a focused manner, permitting the practice of precision medicine. In this review, we will discuss the clinical manifestations and underlying biology of the genetic causes of familial pneumothorax.<br />Competing Interests: Competing interests: None declared.<br /> (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
Details
- Language :
- English
- ISSN :
- 1468-3296
- Volume :
- 73
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Thorax
- Publication Type :
- Academic Journal
- Accession number :
- 29288214
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2017-211169