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The good and bad faces of the CXCR4 chemokine receptor.
- Source :
-
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2018 Feb; Vol. 95, pp. 121-131. Date of Electronic Publication: 2017 Dec 27. - Publication Year :
- 2018
-
Abstract
- Chemokines are chemotactic cytokines that promote cell migration and activation under homeostatic and inflammatory conditions. Chemokines bind to seven transmembrane-spanning receptors that are coupled to heterotrimeric guanine nucleotide-binding (G) proteins, which are the responsible for intracellularly transmitting the activating signals for cell migration. Hematopoiesis, vascular development, lymphoid organ morphogenesis, cardiogenesis and neural differentiation are amongst the processes involving chemokine function. In addition, immune cell trafficking from bone marrow to blood circulation, and from blood and lymph to lymphoid and inflamed tissues, is tightly regulated by chemokines both under physiological conditions and also in autoimmune diseases. Furthermore, chemokine binding to their receptors stimulate trafficking to and positioning of cancer cells into target tissues and organs during tumour dissemination. The CXCL12 chemokine (also known as stromal-cell derived factor-1α, SDF-1α) plays key roles in hematopoiesis and lymphoid tissue architecture, in cardiogenesis, vascular formation and neurogenesis, as well as in the trafficking of solid and hematological cancer cell types. CXCL12 binds to the CXCR4 receptor, a multi-facetted molecule which tightly mirrors CXCL12 functions in homeostasis and disease. This review addresses the important roles of the CXCR4-CXCL12 axis in homeostasis, specially focusing in hematopoiesis, as well as it provides a picture of CXCR4 as mediator of cancer cell spreading, and a view of the available CXCR4 antagonists in different cancer types.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Chemokine CXCL12 chemistry
Drugs, Investigational therapeutic use
Humans
Ligands
Neoplasm Proteins antagonists & inhibitors
Neoplasm Proteins chemistry
Neoplasm Proteins metabolism
Neoplasms drug therapy
Neoplasms metabolism
Protein Conformation
Protein Multimerization
Receptors, CXCR4 antagonists & inhibitors
Receptors, CXCR4 chemistry
Chemokine CXCL12 metabolism
Hematopoiesis drug effects
Models, Biological
Models, Molecular
Receptors, CXCR4 metabolism
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5875
- Volume :
- 95
- Database :
- MEDLINE
- Journal :
- The international journal of biochemistry & cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 29288743
- Full Text :
- https://doi.org/10.1016/j.biocel.2017.12.018