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Prostate cancer susceptibility and growth linked to Y chromosome genes.
- Source :
-
Frontiers in bioscience (Elite edition) [Front Biosci (Elite Ed)] 2018 Mar 01; Vol. 10 (3), pp. 423-436. Date of Electronic Publication: 2018 Mar 01. - Publication Year :
- 2018
-
Abstract
- The role of Y chromosome in prostate cancer progression and incidence is not well known. Among the 46 chromosomes, Y chromosome determines the male gender. The Y chromosome is smaller than the X chromosome and contains only 458 genes compared to over 2000 genes found in the X chromosome. The Y chromosome is prone to high mutation rates, created exclusively in sperm cells due to the highly oxidative environment of the testis. Y chromosome harbors epigenetic information, which affects the expression of genes associated with the incidence and progression of prostate cancer. In this review, we focus on Y chromosome related genetic abnormalities, likely to be involved in the development and progression of prostate cancer.
Details
- Language :
- English
- ISSN :
- 1945-0508
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Frontiers in bioscience (Elite edition)
- Publication Type :
- Academic Journal
- Accession number :
- 29293466
- Full Text :
- https://doi.org/10.2741/e830