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Prostate cancer susceptibility and growth linked to Y chromosome genes.

Authors :
Patel R
Khalifa AO
Isali I
Shukla S
Source :
Frontiers in bioscience (Elite edition) [Front Biosci (Elite Ed)] 2018 Mar 01; Vol. 10 (3), pp. 423-436. Date of Electronic Publication: 2018 Mar 01.
Publication Year :
2018

Abstract

The role of Y chromosome in prostate cancer progression and incidence is not well known. Among the 46 chromosomes, Y chromosome determines the male gender. The Y chromosome is smaller than the X chromosome and contains only 458 genes compared to over 2000 genes found in the X chromosome. The Y chromosome is prone to high mutation rates, created exclusively in sperm cells due to the highly oxidative environment of the testis. Y chromosome harbors epigenetic information, which affects the expression of genes associated with the incidence and progression of prostate cancer. In this review, we focus on Y chromosome related genetic abnormalities, likely to be involved in the development and progression of prostate cancer.

Details

Language :
English
ISSN :
1945-0508
Volume :
10
Issue :
3
Database :
MEDLINE
Journal :
Frontiers in bioscience (Elite edition)
Publication Type :
Academic Journal
Accession number :
29293466
Full Text :
https://doi.org/10.2741/e830