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Primary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2017 Dec 27; Vol. 217 (1), pp. 3-11. - Publication Year :
- 2017
-
Abstract
- Influenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality during annual epidemics. Two distinct lineages of IBV are distinguished, based on variation in hemagglutinin (HA): B/Victoria/2/87-like (B/Vic) and B/Yamagata/16/88-like (B/Yam). Here, we show that, in humans, primary IBV infection with either lineage induces HA-specific antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies. IBV infection induced antibodies specific to the HA head and stalk, but only HA stalk-specific antibodies mediated ADCC efficiently and displayed cross-reactivity with IBV of both lineages. This corresponds to recent findings that 2 points of contact between the effector and target cell (ie, HA and sialic acid, respectively, and the fragment crystallizable [Fc] domain and Fcγ receptor IIIα, respectively) are required for efficient ADCC activity and that antibodies specific for the receptor-binding site located in the head domain of HA therefore fail to mediate ADCC. Potentially, ADCC-mediating antibodies directed to the HA stalk of IBV contribute to cross-protective immunity to IBV of both lineages.<br /> (© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Subjects :
- Child
Child, Preschool
Cross-Sectional Studies
Female
Genotype
Humans
Infant
Influenza B virus classification
Influenza B virus genetics
Male
Antibodies, Viral blood
Antibody-Dependent Cell Cytotoxicity
Cross Reactions
Hemagglutinin Glycoproteins, Influenza Virus immunology
Influenza B virus immunology
Influenza, Human immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 217
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 29294018
- Full Text :
- https://doi.org/10.1093/infdis/jix546