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Periodic microstructures of blood capillaries revealed by synchrotron X-ray multi-resolution microscopic analysis.
- Source :
-
Biomedical optics express [Biomed Opt Express] 2017 Nov 30; Vol. 8 (12), pp. 5825-5833. Date of Electronic Publication: 2017 Nov 30 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Cardiovascular diseases are closely related to structural blood capillaries lesions. Herein, microscopic investigations of mouse blood capillaries were performed at multiple spatial resolution by using synchrotron X-ray in-line phase contrast tomography and scanning transmission X-ray microscopy (STXM). The chemically fixed blood capillaries without any contrast agents were selected. For the first time, a periodic bamboo-shaped structure was observed at nanoscale resolution by STXM, and the three-dimensional tomographic slices at sub-micrometer resolution further confirmed the periodic wave profile of the blood capillaries. Then, a periodic microstructural model was suggested based on the microscopic images. By using high-performance imaging techniques, this work provides a better understanding of the relationship between the structure and function of blood capillaries, will be helpful in elucidating the causes of cardiovascular system diseases.<br />Competing Interests: The authors declare that there are no conflicts of interest related to this article.
Details
- Language :
- English
- ISSN :
- 2156-7085
- Volume :
- 8
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biomedical optics express
- Publication Type :
- Academic Journal
- Accession number :
- 29296507
- Full Text :
- https://doi.org/10.1364/BOE.8.005825