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Maintenance of Ideal Cardiovascular Health and Coronary Artery Calcium Progression in Low-Risk Men and Women in the Framingham Heart Study.
- Source :
-
Circulation. Cardiovascular imaging [Circ Cardiovasc Imaging] 2018 Jan; Vol. 11 (1), pp. e006209. - Publication Year :
- 2018
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Abstract
- Background: Ideal cardiovascular health (CVH) is associated with a lower risk of cardiovascular disease and freedom from coronary artery calcium (CAC). Prospective data on the association between maintenance of optimal CVH and the progression of subclinical coronary atherosclerosis are limited. We assessed the influence of unfavorable versus favorable CVH on the incidence of CAC progression.<br />Methods and Results: The study population consisted of 1119 FHS (Framingham Heart Study) participants who attended the serial FHS MDCT I and MDCT II study (Multi-Detector Computed Tomography) and had a zero Agatston CAC score at baseline. CVH status was defined using 6 CVH metrics from the American Heart Association definition. CAC progression was defined by an increase in Agatston CAC score to ≥3.4. Generalized estimating equations were applied to identify significant associations of CAC progression with both the baseline measurement of CVH and the longitudinal maintenance of CVH. After follow-up (mean, 6.1 years), we observed CAC progression in 191 participants (17.1%). Participants with unfavorable CVH at baseline had a greater risk of CAC progression (odds ratio, 2.43; 95% confidence interval, 1.40-4.23; P =0.0017). In addition, each unit decrease in ideal CVH metric was associated with an increase in CAC progression (odds ratio, 1.15; 95% confidence interval, 0.99-1.34; P =0.067), after adjustment for baseline ideal CVH metrics.<br />Conclusions: Significant associations between an unfavorable CVH profile and CAC progression support public health measures that seek to prevent cardiovascular disease by promoting favorable CVH profiles in persons free of clinical and subclinical cardiovascular disease.<br /> (© 2018 American Heart Association, Inc.)
- Subjects :
- Aged
Biomarkers analysis
Cardiovascular Diseases epidemiology
Disease Progression
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk Assessment methods
Risk Factors
United States epidemiology
Vascular Calcification epidemiology
Cardiovascular Diseases diagnostic imaging
Cardiovascular Diseases pathology
Health Status Indicators
Vascular Calcification diagnostic imaging
Vascular Calcification pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0080
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Circulation. Cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 29305347
- Full Text :
- https://doi.org/10.1161/CIRCIMAGING.117.006209