DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin.

Authors :: Toğay VA
Sevimli TS
Sevimli M
Çelik DA
Özçelik N
Source :: Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2018 Jan; Vol. 825, pp. 15-18. Date of Electronic Publication: 2017 Nov 04.
Publication Year :: 2018
Abstract: Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Subjects :: Animals
Body Weight
Case-Control Studies
Comet Assay
Diabetes Mellitus, Experimental genetics
Male
Rats
Silybin pharmacology
DNA Damage drug effects
Diabetes Mellitus, Experimental drug therapy
Silybin administration & dosage

Language :: English
ISSN :: 1879-3592
Volume :: 825
Database :: MEDLINE
Journal :: Mutation research. Genetic toxicology and environmental mutagenesis
Publication Type :: Academic Journal
Accession number :: 29307371
Full Text :: https://doi.org/10.1016/j.mrgentox.2017.11.002

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