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The Ferret as a Surgical Model for Vocal Fold Scar Creation and Treatment.
- Source :
-
The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] 2018 Mar; Vol. 127 (3), pp. 146-154. Date of Electronic Publication: 2018 Jan 09. - Publication Year :
- 2018
-
Abstract
- Objectives: To develop a vocal fold (VF) scarring procedure in the ferret, characterize the scars histologically, and test the injectability of the lamina propria (LP). Secondarily, to compare laryngeal anatomy of the ferret with rat and rabbit.<br />Materials and Methods: The larynges of 18 male ferrets were prepared by unilateral scarring, and normal larynges from 6 female Wistar rats and 5 male albino rabbits were used for comparative purposes. For scarring, the right VF were electrocauterized, ablating the entire LP. Prior to harvesting the larynges at 4 and 16 weeks, each ferret was re-anesthetized, and in 3 animals, India ink was injected into the LPs of both normal and scarred VFs.<br />Results: Laryngoscopic methods and instrumentation for precise visualization, scarring, and injection were developed. The scarred VFs had reduced hyaluronic acid and increased collagen type I, III, and fibronectin compared with normal VFs. The 2 timepoints (4 and 16 weeks) differed significantly only in collagen type III level (levels were higher at 4 weeks). Injected ink migrated from scarred LP to muscle layer just beneath the scarred tissue 3 hours after injection.<br />Conclusion: The ferret is a promising species for creation and experimental treatment of vocal fold scar.
- Subjects :
- Animals
Collagen Type I analysis
Collagen Type III analysis
Female
Ferrets
Fibronectins analysis
Models, Anatomic
Rabbits
Rats
Vocal Cords pathology
Cicatrix etiology
Cicatrix metabolism
Cicatrix pathology
Electrocoagulation methods
Laryngoscopy instrumentation
Laryngoscopy methods
Mucous Membrane pathology
Mucous Membrane surgery
Vocal Cords surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1943-572X
- Volume :
- 127
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Annals of otology, rhinology, and laryngology
- Publication Type :
- Academic Journal
- Accession number :
- 29310440
- Full Text :
- https://doi.org/10.1177/0003489417750165