Aristololactam derivatives from the fruits of Aristolochia contorta Bunge.

Authors :: Ma HW
Dong CZ
Zhou XM
Bu MM
Yu SQ
Source :: Natural product research [Nat Prod Res] 2018 Nov; Vol. 32 (21), pp. 2505-2509. Date of Electronic Publication: 2018 Jan 09.
Publication Year :: 2018
Abstract: Three new aristololactam derivatives, aristololactam W-Y (1-3), and three known compounds (4-6) were isolated from the fruits of Aristolochia contorta Bunge. Compounds 1 and 2 represent the first example of an N-CH <subscript>2</subscript> OCH <subscript>3</subscript> aristololactam derivative from natural products. Their structures were elucidated by 1D/2D NMR and HRESIMS spectra. All of the isolated compounds were evaluated for their insecticidal activity against 4th instar larvae of Aedes aegypti. Compound 4 displayed insecticidal activity with LC <subscript>50</subscript> value of 3.54 μg/mL.