Back to Search
Start Over
Asymmetric Synthesis and Biological Activities of Pactamycin-Inspired Aminocyclopentitols.
- Source :
-
Organic letters [Org Lett] 2018 Jan 19; Vol. 20 (2), pp. 397-400. Date of Electronic Publication: 2018 Jan 10. - Publication Year :
- 2018
-
Abstract
- Pactamycin is a structurally unique aminocyclitol antibiotic with broad-spectrum cell growth inhibitory activity. To explore the bountiful activity of the aminocyclitol core of pactamycin, an efficient, modular, and asymmetric synthesis of aminocyclopentitols resembling the pactamycin pharmacophore has been developed employing a SmI <subscript>2</subscript> -mediated imino-pinacol coupling strategy. Two of the compounds exhibited antitumor activity against A375 melanoma cells.
- Subjects :
- Anti-Bacterial Agents
Molecular Structure
Pactamycin chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 29319326
- Full Text :
- https://doi.org/10.1021/acs.orglett.7b03681