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Chemical decontamination of iPS cell-derived neural cell mixtures.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2018 Feb 01; Vol. 54 (11), pp. 1355-1358. - Publication Year :
- 2018
-
Abstract
- This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.
- Subjects :
- Alkaline Phosphatase metabolism
Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Antineoplastic Agents metabolism
Camptothecin chemical synthesis
Camptothecin chemistry
Camptothecin metabolism
Camptothecin pharmacology
Cattle
Cell Line
Cell Membrane Permeability
DNA Damage
Humans
Induced Pluripotent Stem Cells cytology
Induced Pluripotent Stem Cells enzymology
Irinotecan
Neural Stem Cells cytology
Neural Stem Cells enzymology
Neurons cytology
Neurons drug effects
Phosphorylation
Antineoplastic Agents pharmacology
Camptothecin analogs & derivatives
Induced Pluripotent Stem Cells drug effects
Neural Stem Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 54
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 29350722
- Full Text :
- https://doi.org/10.1039/c7cc08686e