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Antimicrobial Peptide Resistance Mechanism Contributes to Staphylococcus aureus Infection.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2018 Mar 13; Vol. 217 (7), pp. 1153-1159. - Publication Year :
- 2018
-
Abstract
- Antimicrobial peptides (AMPs) constitute an important part of innate host defense. Possibly limiting the therapeutic potential of AMPs is the fact that bacteria have developed AMP resistance mechanisms during their co-evolution with humans. However, there is no direct evidence that AMP resistance per se is important during an infection. Here we show that the Staphylococcus aureus Pmt ABC transporter defends the bacteria from killing by important human AMPs and elimination by human neutrophils. By showing that Pmt contributes to virulence during skin infection in an AMP-dependent manner, we provide evidence that AMP resistance plays a key role in bacterial infection.
- Subjects :
- ATP-Binding Cassette Transporters genetics
Animals
Drug Resistance, Bacterial
Humans
Mice
Protein Conformation
Staphylococcal Skin Infections drug therapy
Staphylococcal Skin Infections microbiology
Cathelicidins
ATP-Binding Cassette Transporters metabolism
Anti-Bacterial Agents pharmacology
Antimicrobial Cationic Peptides pharmacology
Neutrophils physiology
Staphylococcus aureus drug effects
Staphylococcus aureus metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 217
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 29351622
- Full Text :
- https://doi.org/10.1093/infdis/jiy024