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The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8 + T Cells via SHIP-1.
- Source :
-
Frontiers in immunology [Front Immunol] 2017 Dec 06; Vol. 8, pp. 1696. Date of Electronic Publication: 2017 Dec 06 (Print Publication: 2017). - Publication Year :
- 2017
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Abstract
- We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8 <superscript>+</superscript> T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-155 on CD8 <superscript>+</superscript> T cells is mediated by T-bet. T-bet levels in CTL were controlled in vivo by miR-155 via SH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet. Our studies reveal an important and unexpected signaling axis between miR-155, T-bet, and SHIP-1 in in vivo CTL responses and suggest an important signaling module that regulates effector CTL immunity.
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29358931
- Full Text :
- https://doi.org/10.3389/fimmu.2017.01696