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Obesity is a significant susceptibility factor for idiopathic AA amyloidosis.
- Source :
-
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2018 Mar; Vol. 25 (1), pp. 37-45. Date of Electronic Publication: 2018 Jan 24. - Publication Year :
- 2018
-
Abstract
- Background: To investigate obesity as susceptibility factor in patients with idiopathic AA amyloidosis.<br />Methods: Clinical, biochemical and genetic data were obtained from 146 patients with AA amyloidosis. Control groups comprised 40 patients with long-standing inflammatory diseases without AA amyloidosis and 56 controls without any inflammatory disease.<br />Findings: Patients with AA amyloidosis had either familial Mediterranean fever (FMF) or long-standing rheumatic diseases as underlying inflammatory disease (n = 111, median age 46 years). However, in a significant proportion of patients with AA amyloidosis no primary disease was identified (idiopathic AA; n = 37, median age 60 years). Patients with idiopathic AA amyloidosis were more obese and older than patients with AA amyloidosis secondary to FMF or rheumatic diseases. Serum leptin levels correlated with the body mass index (BMI) in all types of AA amyloidosis. Elevated leptin levels of more than 30 µg/l were detected in 18% of FMF/rheumatic + AA amyloidosis and in 40% of patients with idiopathic AA amyloidosis (p = .018). Finally, the SAA1 polymorphism was confirmed as a susceptibility factor for AA amyloidosis irrespective of the type of the disease.<br />Conclusions: Obesity, age and the SAA1 polymorphism are susceptibility factors for idiopathic AA amyloidosis. Recent advances in treatment of FMF and rheumatic disorders will decrease the incidence of AA amyloidosis due to these diseases. Idiopathic AA, however, might be an emerging problem in the ageing and increasingly obese population.
- Subjects :
- Adult
Aged
Aged, 80 and over
Familial Mediterranean Fever blood
Familial Mediterranean Fever complications
Familial Mediterranean Fever epidemiology
Familial Mediterranean Fever genetics
Female
Humans
Leptin genetics
Male
Middle Aged
Rheumatic Diseases blood
Rheumatic Diseases complications
Rheumatic Diseases epidemiology
Rheumatic Diseases genetics
Serum Amyloid A Protein metabolism
Amyloidosis blood
Amyloidosis epidemiology
Amyloidosis etiology
Amyloidosis genetics
Genetic Predisposition to Disease
Leptin blood
Obesity blood
Obesity complications
Obesity epidemiology
Obesity genetics
Polymorphism, Genetic
Serum Amyloid A Protein genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1744-2818
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
- Publication Type :
- Academic Journal
- Accession number :
- 29364741
- Full Text :
- https://doi.org/10.1080/13506129.2018.1429391