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3D Printed "Starmix" Drug Loaded Dosage Forms for Paediatric Applications.
- Source :
-
Pharmaceutical research [Pharm Res] 2018 Jan 16; Vol. 35 (2), pp. 34. Date of Electronic Publication: 2018 Jan 16. - Publication Year :
- 2018
-
Abstract
- Purpose: Three- dimensional (3D) printing has received significant attention as a manufacturing process for pharmaceutical dosage forms. In this study, we used Fusion Deposition Modelling (FDM) in order to print "candy - like" formulations by imitating Starmix® sweets to prepare paediatric medicines with enhanced palatability.<br />Methods: Hot melt extrusion processing (HME) was coupled with FDM to prepare extruded filaments of indomethacin (IND), hypromellose acetate succinate (HPMCAS) and polyethylene glycol (PEG) formulations and subsequently feed them in the 3D printer. The shapes of the Starmix® objects were printed in the form of a heart, ring, bottle, ring, bear and lion. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier Transform Infra-red Spectroscopy (FT-IR) and confocal Raman analysis were used to assess the drug - excipient interactions and the content uniformity.<br />Results: Physicochemical analysis showed the presence of molecularly dispersed IND in the printed tablets. In vivo taste masking evaluation demonstrated excellent masking of the drug bitterness. The printed forms were evaluated for drug dissolution and showed immediate IND release independently of the printed shape, within 60 min.<br />Conclusions: 3D printing was used successfully to process drug loaded filaments for the development of paediatric printed tablets in the form of Starmix® designs.
- Subjects :
- Administration, Oral
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Child
Drug Liberation
Feasibility Studies
Humans
Indomethacin pharmacokinetics
Methylcellulose analogs & derivatives
Methylcellulose chemistry
Polyethylene Glycols chemistry
Tablets
Taste
Taste Perception
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Drug Compounding methods
Excipients chemistry
Indomethacin administration & dosage
Printing, Three-Dimensional
Subjects
Details
- Language :
- English
- ISSN :
- 1573-904X
- Volume :
- 35
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pharmaceutical research
- Publication Type :
- Academic Journal
- Accession number :
- 29368113
- Full Text :
- https://doi.org/10.1007/s11095-017-2284-2