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Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system.

Authors :
Lannes N
Eppler E
Etemad S
Yotovski P
Filgueira L
Source :
Oncotarget [Oncotarget] 2017 Dec 11; Vol. 8 (69), pp. 114393-114413. Date of Electronic Publication: 2017 Dec 11 (Print Publication: 2017).
Publication Year :
2017

Abstract

Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the pathogenesis of neurodegenerative diseases and contribute to aging. They play an important role in sustaining and breaking the blood-brain barrier. As innate immune cells, they contribute substantially to the immune response against infectious agents affecting the CNS. They play also a major role in the growth of tumours of the CNS. Microglia are consequently the key cell population linking the nervous and the immune system. This review covers all different aspects of microglia biology and pathology in a comprehensive way.<br />Competing Interests: CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Details

Language :
English
ISSN :
1949-2553
Volume :
8
Issue :
69
Database :
MEDLINE
Journal :
Oncotarget
Publication Type :
Academic Journal
Accession number :
29371994
Full Text :
https://doi.org/10.18632/oncotarget.23106