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Systemic sclerosis associated interstitial lung disease - individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group.
- Source :
-
Arthritis research & therapy [Arthritis Res Ther] 2018 Jan 30; Vol. 20 (1), pp. 17. Date of Electronic Publication: 2018 Jan 30. - Publication Year :
- 2018
-
Abstract
- Background: Interstitial lung disease in systemic sclerosis (SSc-ILD) is a major cause of SSc-related death. Imunosuppressive treatment (IS) is used in patients with SSc for various organ manifestations mainly to ameliorate progression of SSc-ILD. Data on everyday IS prescription patterns and clinical courses of lung function during and after therapy are scarce.<br />Methods: We analysed patients fulfilling American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) 2013 criteria for SSc-ILD and at least one report of IS. Types of IS, pulmonary function tests (PFT) and PFT courses during IS treatment were evaluated.<br />Results: EUSTAR contains 3778/11,496 patients with SSc-ILD (33%), with IS in 2681/3,778 (71%). Glucocorticoid (GC) monotherapy was prescribed in 30.6% patients with GC combinations plus cyclophosphamide (CYC) (11.9%), azathioprine (AZA) (9.2%), methotrexate (MTX) (8.7%), or mycophenolate mofetil (MMF) (7.3%). Intensive IS (MMF + GC, CYC or CYC + GC) was started in patients with the worst PFTs and ground glass opacifications on imaging. Patients without IS showed slightly less worsening in forced vital capacity (FVC) when starting with FVC 50-75% or >75%. GC showed negative trends when starting with FVC <50%. Regarding diffusing capacity for carbon monoxide (DLCO), negative DLCO trends were found in patients with MMF.<br />Conclusions: IS is broadly prescribed in SSc-ILD. Clusters of clinical and functional characteristics guide individualised treatment. Data favour distinguished decision-making, pointing to either watchful waiting and close monitoring in the early stages or start of immunosuppressive treatment in moderately impaired lung function. Advantages of specific IS are difficult to depict due to confounding by indication. Data do not support liberal use of GC in SSc-ILD.
- Subjects :
- Adult
Aged
Cyclophosphamide therapeutic use
Drug Therapy, Combination
Female
Humans
Lung pathology
Lung physiopathology
Lung Diseases, Interstitial complications
Lung Diseases, Interstitial physiopathology
Male
Methotrexate therapeutic use
Middle Aged
Mycophenolic Acid therapeutic use
Precision Medicine methods
Respiratory Function Tests
Scleroderma, Systemic complications
Immunosuppressive Agents therapeutic use
Lung drug effects
Lung Diseases, Interstitial drug therapy
Scleroderma, Systemic drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6362
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Arthritis research & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 29382380
- Full Text :
- https://doi.org/10.1186/s13075-018-1517-z